5AM Venture Management, LLC 13F Holdings

CIK 000160395 · SAN FRANCISCO, CA

As of Sep 30, 2025, 5AM Venture Management, LLC reported 25 positions worth $273.0M in its SEC Form 13F filing.

Top 25 holdings

SecurityTickerSectorSharesValue% of portfolio
SKYE BIOSCIENCE INCSKYEHealthcare9,681,763$38.0M13.94%
ENTRADA THERAPEUTICS INCTRDAHealthcare4,256,379$24.7M9.04%
PHARVARIS N VPHVSHealthcare797,600 9.9M7.29%
CAMP4 THERAPEUTICS CORPCAMPHealthcare5,869,091 7.6M6.45%
CENTESSA PHARMACEUTICALS PLCCNTAHealthcare680,945 6.5M6.05%
VIRIDIAN THERAPEUTICS INCVRDNHealthcare736,595 5.9M5.82%
ENLIVEN THERAPEUTICS INCELVNHealthcare772,477 5.8M5.79%
EYEPOINT PHARMACEUTICALS INCEYPTHealthcare1,050,000 5.0M5.48%
DIANTHUS THERAPEUTICS INCDNTHHealthcare365,053 4.4M5.26%
TYRA BIOSCIENCES INCTYRAHealthcare939,298 3.1M4.81%
CELLDEX THERAPEUTICS INC NEWCLDXHealthcare497,270 2.9M4.71%
ERASCA INCERASHealthcare5,405,404 1.8M4.32%
PRAXIS PRECISION MEDICINES INCPRAXHealthcare170,000$9.0M3.30%
GH RESEARCH PLCGHRSHealthcare572,665$8.2M3.00%
TECTONIC THERAPEUTIC INCTECXHealthcare511,660$8.0M2.94%
BIOHAVEN LTDBHVNHealthcare478,972$7.2M2.63%
ARTIVA BIOTHERAPEUTICS INCARTVHealthcare2,353,304$6.8M2.47%
SURROZEN INCSRZNHealthcare310,000$4.0M1.46%
PROTARA THERAPEUTICS INCTARAHealthcare800,000$3.5M1.27%
ALECTOR INCALECHealthcare995,841$2.9M1.08%
SILENCE THERAPEUTICS PLCSLNHealthcare476,200$2.5M0.91%
ADVERUM BIOTECHNOLOGIES INCADVMHealthcare541,666$2.5M0.90%
RALLYBIO CORPRLYBHealthcare3,630,724 .8M0.66%
ZENTALIS PHARMACEUTICALS INCZNTLHealthcare490,000$739.9K0.27%
MERSANA THERAPEUMRSNHealthcare52,200$405.1K0.15%