Opaleye Management Inc. 13F Holdings

CIK 0001595855 · Cambridge, MA

As of Sep 30, 2025, Opaleye Management Inc. reported 43 positions worth $707.3M in its SEC Form 13F filing.

Top 25 holdings

SecurityTickerSectorSharesValue% of portfolio
HARROW INCHROWHealthcare3,905,000 88.1M26.60%
ETON PHARMACEUTICALS INCETONHealthcare2,860,000$62.1M8.79%
LIQUIDIA CORPLQDAHealthcare2,615,000$59.5M8.41%
RHYTHM PHARMACEUTICALS INCRYTMHealthcare461,700$46.6M6.59%
IMMUNOME INCIMNM—3,185,000$37.3M5.27%
SANUWAVE HEALTH INCSNWVHealthcare980,000$36.7M5.19%
CODEXIS INCCDXSHealthcare12,795,000$31.2M4.41%
TG THERAPEUTICS INCTGTXHealthcare535,000 9.3M2.73%
OCULAR THERAPEUTIX INCOCULHealthcare1,595,000 8.6M2.64%
CG ONCOLOGY INCCGONHealthcare410,000 6.5M2.33%
STOKE THERAPEUTICS INCSTOKHealthcare682,017 6.0M2.27%
APOGEE THERAPEUTICS INCAPGEHealthcare363,257 4.4M2.04%
ALKERMES PLCALKSHealthcare450,000 3.5M1.91%
DISC MEDICINE INCIRONHealthcare193,773 2.8M1.81%
SAREPTA THERAPEUTICS INCSRPTHealthcare585,000 1.3M1.59%
LARIMAR THERAPEUTICS INCLRMRHealthcare3,720,867 0.6M1.49%
XOMA ROYALTY CORPXOMAHealthcare255,087$9.8M1.39%
REZOLUTE INCRZLTHealthcare903,442$8.5M1.20%
ARVINAS INCARVNHealthcare987,818$8.4M1.19%
EDGEWISE THERAPEUTICS INCEWTXHealthcare500,000$8.1M1.15%
ANNEXON INCANNXHealthcare2,600,000$7.9M1.12%
GOSSAMER BIO INCGOSSHealthcare2,725,000$7.2M1.01%
PROTAGONIST THERAPEUTICS INCPTGXHealthcare105,000$7.0M0.99%
JOURNEY MEDICAL CORPDERMHealthcare971,064$6.9M0.98%
SOL GEL TECHNOLOGIESSLGLHealthcare204,835$6.0M0.84%