SPHERA FUNDS MANAGEMENT LTD. 13F Holdings

CIK 0001496201 · Tel Aviv, L3

As of Sep 30, 2025, SPHERA FUNDS MANAGEMENT LTD. reported 105 positions worth $474.1M in its SEC Form 13F filing.

Top 25 holdings

SecurityTickerSectorSharesValue% of portfolio
TEVA PHARMACEUTICAL INDUSTRIES LTDTEVAHealthcare1,507,025$30.4M6.42%
NICE LTDNICETechnology157,400$22.8M4.81%
TOWER SEMICONDUCTOR LTDTSEMTechnology311,802$22.5M4.76%
CIDARA THERAPEUTICS INCCDTXHealthcare175,743 6.8M3.55%
MERUS NVMRUSHealthcare150,000 4.1M2.98%
NOVA LTDNVMITechnology43,896 4.0M2.96%
INVESCO QQQ TRUST SERIES 1QQQ—22,960 3.8M2.91%
BIOGEN INCBIIBHealthcare82,738 1.6M2.44%
ULTRAGENYX PHARMACEUTICAL INCRAREHealthcare352,558 0.6M2.24%
ASTRAZENECA PLCAZNHealthcare135,060 0.4M2.19%
SANOFISNYEquity219,515 0.4M2.19%
CYTOKINETICS INCCYTKHealthcare161,517$8.9M1.87%
BRIDGEBIO PHARMA INCBBIOHealthcare170,746$8.9M1.87%
MINERALYS THERAPEUTICS INCMLYSHealthcare219,910$8.3M1.76%
AMICUS THERAPEUTICS INCFOLDHealthcare991,142$7.8M1.65%
ELI LILLY & COLLYHealthcare10,040$7.7M1.62%
JOHNSON & JOHNSONJNJHealthcare40,831$7.6M1.60%
FORTE BIOSCIENCES INC——474,309$7.1M1.50%
TREVI THERAPEUTICS INCTRVIHealthcare773,157$7.1M1.49%
STRUCTURE THERAPEUTICS INCGPCRHealthcare223,931$6.3M1.32%
SYNDAX PHARMACEUTICALS INCSNDXHealthcare387,716$6.0M1.26%
NOVO NORDISK A SNVOHealthcare105,677$5.9M1.24%
ABBVIE INCABBVEquity25,256$5.8M1.23%
UNIQURE NVQUREHealthcare99,900$5.8M1.23%
PRAXIS PRECISION MEDICINES INCPRAXHealthcare107,901$5.7M1.21%